Hypnotic doses of these barbiturates usually do not surface to noticeably impair uterine activity through labor; full anesthetic doses of barbiturates lessen the pressure and frequency of uterine contractions; administration of sedative-hypnotic barbiturates on the mom in the course of labor may cause respiratory despair while in the new child

fentanyl transmucosal and pentobarbital both increase sedation. Keep away from or Use Alternate Drug. Limit use to people for whom alternative therapy possibilities are insufficient

pentobarbital will lower the level or influence of voriconazole by impacting hepatic enzyme CYP2C9/10 metabolism. Slight/Significance Unfamiliar.

pentobarbital will lower the extent or impact of buprenorphine buccal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.

pentobarbital will increase toxicity of buprenorphine, long-performing injection by pharmacodynamic synergism. Modify Therapy/Watch Carefully. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases chance of adverse reactions together with overdose, respiratory despair, and Dying. Cessation of benzodiazepines or other CNS depressants is favored in most cases.

pentobarbital will lessen the extent or effect of tipranavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.

pentobarbital will get more info lower the level or outcome of midazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.

pentobarbital will improve the degree or result of ivosidenib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of ivosidenib with potent CYP3A4 inducers lowered ivosidenib plasma concentrations.

pentobarbital will decrease the level or impact of efavirenz by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unfamiliar.

pentobarbital will decrease the level or outcome of lumefantrine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with potent CYP3A4 inducers may end up in decreased serum concentrations and loss of antimalarial efficacy

pentobarbital will lower the extent or result of fludrocortisone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

pentobarbital will reduce the extent or influence of diazepam buccal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Sturdy or moderate CYP3A4 inducers may increase fee of diazepam elimination; therefore, efficacy of diazepam may very well be lowered.

With therapeutic doses of TCAs, barbiturates raise metabolism and decrease blood concentrations of TCAs.

pentobarbital will lower the level or outcome of atazanavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unknown.